Cholesterol feeding induces cholesterol-rich VLDL in atherosclerosis-susceptible mice regardless of dietary fat content
1993
LeBoeuf, R.C. | Tsao, W.W. | Kirk, E. | Childs, M.T.
We describe changes in the plasma lipid and apolipoprotein (apo) levels and composition of plasma lipoproteins from C57BL/6 mice fed low fat or high fat diets of differing fatty acid composition and cholesterol content. C57BL/6 mice were used because of their responsiveness, in terms of plasma lipid levels and atherosclerosis susceptibility, to diets rich in saturated fat and cholesterol. Mice were fed one of eight semi-synthetic diets for five weeks: low fat (22 g/kg corn oil) or high fat (cocoa butter, safflower oil, or salmon oil at 135 g/kg) and containing either 0.17 g/kg or 5 g/kg cholesterol. Both type of fat and cholesterol content influenced the concentrations of plasma lipids. In particular, the VLDL fraction of mice fed high cholesterol diets was enriched in cholesterol, regardless of dietary fat content. Atherogenesis in fat fed C57BL/6 mice is always accompanied by decreased HDL cholesterol levels. Because decreased HDL cholesterol levels were not observed here, we hypothesize that beta VLDL formation is not responsible for lesion formation in C57BL/6 mice.
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