Synthesis of 3-benzyl-2-phenylthiazolidin-4-ones and effect of length of spacer between thiazolidine and phenyl rings on fungitoxicity against various phytopathogens
2011
Sidhu, Anjali | Sharma, Vineet K. | Garg, Anita
Chemical solutions are always needed at the time of acute attack and spread of disease. There is a need of less toxic, environmentally safe chemicals that could help in the eradication of the pathogen. To keep the aim, series of 3-benzyl-2-phenylthiazolidin-4-ones were synthesized and were screened in vitro for fungitoxicity against A. alternata, C. capsici, F. oxysporum, M. roridum and U. tritici by spore germination inhibition method. The compounds have shown moderate to promising antifungal potential against. The effect of increased length of molecule on fungitoxicity was studied. The antifungal activity has been found to increase against A. alternata and F. oxysporum with increase in length of spacer between thiazolidine and phenyl rings but decreases in case of C. capsici and M. roridum. There was no general trend against U. tritici. The results of the present study are at variance as compared to the observations made in case of effect of length of spacer between two phenyl rings in imines and secondary amines
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