Lactobacillus helveticus-MIKI-020 enhances hepatic FGF21 expression and decreases the core body temperature during sleep in mice
Kiriyama, Kohei | Goto, Tsuyoshi | Yamamoto, Hirotaka | Ara, Takeshi | Takahashi, Haruya | Jheng, Huei-Fen | Nomura, Wataru | Inoue, Hiroyasu | Nakata, Rieko | Kawada, Teruo
The onset of sleep has been reported to be accompanied by a decline in the core body temperature (CBT) at the onset of night. The stimulation of hepatic FGF21 by PPARα agonist influences the central nervous system and decreases the CBT. The present study aimed to evaluate the effect of food-derived PPARα activator on hepatic FGF21 expression and CBT regulation using Lactobacillus helveticus-MIKI-020 (LH). The treatment with LH stimulated FGF21 expression in a PPARα-dependent manner in hepatocytes. Furthermore, two weeks of LH treatment decreased the CBT only during sleep in mice. The expression of FGF21 in the liver and the plasma content of FGF21 were significantly higher in the LH feeding group than in the control group. The results present a novel approach to decrease the CBT during sleep, which can potentially improve sleep disorders.
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