Efficient synthesis of 5-hydroxymethyl-, 5-formyl-, and 5-carboxyl-2′-deoxycytidine and their triphosphates
2014
Sun, Qi | Sun, Jian | Gong, Shan-Shan | Wang, Cheng-Jun | Pu, Shou-Zhi | Feng, Fu-De
An efficient P(V)-N activation strategy for the preparation of high-quality 5-hydroxymethyl-, 5-formyl-, and 5-carboxyl-2′-deoxycytidine triphosphates has been developed. The method was also optimized for gram-scale synthesis of the corresponding parent nucleosides from 2′-deoxythymidine.
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Эту запись предоставил National Agricultural Library