Abscinazole-E1, a novel chemical tool for exploring the role of ABA 8′-hydroxylase CYP707A
2011
Okazaki, Mariko | Nimitkeatkai, Hataitip | Muramatsu, Taku | Aoyama, Hikaru | Ueno, Kotomi | Mizutani, Masaharu | Hirai, Nobuhiro | Kondo, S. (Satoru) | Ōnishi, Toshiyuki | Todoroki, Yasushi
We developed abscinazole-E1 (Abz-E1), a specific inhibitor of abscisic acid (ABA) 8′-hydroxylase (CYP707A). This inhibitor was designed and synthesized as an enlarged analogue of uniconazole (UNI), a well-known plant growth retardant, which inhibits a gibberellin biosynthetic enzyme (ent-kaurene oxidase, CYP701A) as well as CYP707A. Our results showed that Abz-E1 functions as a potent inhibitor of CYP707A and a poor inhibitor of CYP701A both in vitro and in vivo. Abz-E1 application to plants resulted in improved desiccation tolerance and an increase in endogenous ABA.
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