Venous responses to salt loading in hypertensive subjects
1984
Takeshita, Akira | Ashihara, Toshiaki | Yamamoto, Kunihiko | Imaizumi, Tsutomu | Hoka, Sumio | Ito, Naoya | Nakamura, Motoomi
A study assessed whether salt loading altered venous distensibility in salt-responsive hypertensive patients, leading to increased blood pressure. A total of 21 subjects with essential hypertension were placed on a low-sodium (70 meq) diet for 7 days, followed by a 7-day high-sodium (345 meq) diet. Blood pressure in 8 patients ("responders") increased over 10% during the high-sodium diet, relative to that on the low-sodium diet. Venous pressure-volume curves were similar between responders and non-responders during the low-sodium diet; however, a shift in the curve towards the pressure axis occurred in responders only, during the high-sodium diet. Phentolamine dosing did not significantly alter the curves for either group on either diet. The study results indicate that salt loading decreased venous distensibility in salt-responsive patients due to non-adrenergic mechanisms, possibly including venal structural changes. (wz)
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