Effects of sodium arsenate exposure on liver fatty acid profiles and oxidative stress in rats
2014
Kharroubi, Wafa | Dhibi, Madiha | Haouas, Zohra | Chreif, Imed | Neffati, Fadoua | Hammami, Mohamed | Sakly, Rachid
The present study aimed to evaluate the effect of arsenic on liver fatty acids (FA) composition, hepatotoxicity and oxidative status markers in rats. Male rats were randomly devised to six groups (n = 10 per group) and exposed to sodium arsenate at a dose of 1 and 10 mg/l for 45 and 90 days. Arsenate exposure is associated with significant changes in the FA composition in liver. A significant increase of saturated fatty acids (SFA) in all treated groups (p < 0.01) and trans unsaturated fatty acids (trans UFA) in rats exposed both for short term for 10 mg/l (p < 0.05) and long term for 1 and 10 mg/l (p < 0.001) was observed. However, the cis UFA were significantly decreased in these groups (p < 0.05). A markedly increase of indicator in cell membrane viscosity expressed as SFA/UFA was reported in the treated groups (p < 0.001). A significant increase in the level of malondialdehyde by 38.3 % after 90 days of exposure at 10 mg/l was observed. Compared to control rats, significant liver damage was observed at 10 mg/l of arsenate by increasing plasma marker enzymes after 90 days. It is through the histological investigations in hepatic tissues of exposed rats that these damage effects of arsenate were confirmed. The antioxidant perturbations were observed to be more important at groups treated by the high dose (p < 0.05). An increase in the level of protein carbonyls was observed in all treated groups (p < 0.05). The present study provides evidence for a direct effect of arsenite on FA composition disturbance causing an increase of SFA and TFAs isomers, liver dysfunction and oxidative stress. Therefore, arsenate can lead to hepatic damage and propensity towards liver cancer.
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