Attenuation of streptozotocin-induced alterations in acetylcholinesterase and antioxidant system by S-allylcysteine in rats
2013
Saravanan, Ganapathy | Ponmurugan, Ponnusamy
The present study was designed to investigate the effect of the administration of S-allylcysteine (SAC) (150mg/kg body weight for 45 days) on acetylcholinesterase (AChE) activity and antioxidant levels in the brain tissues of streptozotocin-induced diabetic rats. The levels of glucose, TBARS, hydroperoxide and acetylcholinesterase were increased significantly whereas the levels of plasma insulin, reduced glutathione, superoxide dismutase and catalase were decreased in experimental diabetic rats. Administration of SAC to diabetic rats reverted all these parameters. The effect of SAC was compared with glyclazide, a well-known antioxidant and antihyperglycemic drug. In conclusion, the present findings showed that treatment with SAC prevents the increase in AChE activity, lipid peroxidation, and consequently improves the antioxidant system in diabetic rats, indicating that this compound can be considered as possible therapeutics to be investigated in brain disorders associated with the diabetes.
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