ALKBH5-induced demethylation of mono- and dimethylated adenosine
2018
EnsfelderEqual contributions., Timm T. | Kurz, Matthias Q. | Iwan, Katharina | Geiger, Simon | Matheisl, Sarah | Müller, Markus | Beckmann, Roland | Carell, Thomas
RNA contains methylated A-base derivatives. A methylation to m⁶A and then demethylation regulate homeostasis in mRNA. It is assumed that m⁶A is mainly demethylated by the α-ketoglutarate dependent oxidase ALKBH5. Here we show that ALKBH5 also demethylates the dimethylated adenosine m⁶₂A, which is a non-canonical base present in ribosomal RNA.
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