Protective effects of bioconjugates of curcumin with nicotinic and picolinic acids on markers of oxidative stress in human erythrocytes

Rizvi, Syed Ibrahim; Pandey, Archana; Gupta, Ravindra Kumar; Pandey, Kanti Bhooshan

Protective effects of bioconjugates of curcumin with nicotinic and picolinic acids on markers of oxidative stress in human erythrocytes

2015

Rizvi, Syed Ibrahim | Pandey, Archana | Gupta, Ravindra Kumar | Pandey, Kanti Bhooshan

Poor bioavailability and instability beyond the natural pH limit the use of curcumin as a promising drug despite its diverse health promoting effects. With a view to address these issues, the bioconjugates of curcumin with nicotinic acid (di-O-nicotinoyl curcumin) and picolinic acid (di-O-picolinoyl curcumin) were synthesized and their effect on markers of oxidative stress were studied. Results demonstrate that both the bioconjugates elicited higher prevention against oxidative injury induced by tert-butyl hydroperoxide in human erythrocytes in comparison to pure curcumin as evidenced by inhibition of lipid peroxidation (p < 0.01), prevention of hemolysis (p < 0.001), restoration of glutathione (p < 0.005), and -SH groups (p < 0.005) depletion. The study concludes that conjugated curcumin derivatives may be a potential approach to design compounds with improved biological effects and thus enhanced efficacy

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