Isolation of 4-acetyl-benzoxazolin-2-one (4-ABOA) and diferuloylputrescine from an extract of gibberella ear rot-resistant corn that blocks mycotoxin biosynthesis, and the insect toxicity of 4-ABOA and related compounds
1996
Miller, J.D. | Fielder, D.A. | Dowd, P.F. | Norton, R.A. | Collins, F.W.
Bioassay-directed fractionation of an extract of a gibberella ear rot-resistant corn hybrid resulted in the isolation of a fraction that inhibited mycotoxin production, but not growth, of Fusarium culmorum. The fraction contained diferuloylputrescine and a new allelochemical 4-acetyl-benzoxazolin-2-one (4-ABOA). This report describes the isolation of the bioactive fraction and tests of the effect of 4-ABOA on 3-acetyl deoxynivalenol (3ADON) and aflatoxin production. In addition, data are reported on the effects of 4-ABOA and related compounds on a number of insect species and some preliminary studies on the mechanism of insect toxicity. The effect of 4-ABOA on F. culmorum and Aspergillus flavus was similar. Production of toxin was reduced without a concomitant reduction of growth A 50% inhibition of 3ADON production occurred at ca. 4 micromolar and 0.12 mM for alfatoxin 4-ABOA was slightly toxic to Spodoptera frugiperda.
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