Brönsted acid-mediated annulations of 1-cyanocyclopropane-1-carboxylates with arylhydrazines: efficient strategy for the synthesis of 1,3,5-trisubstituted pyrazoles
2016
Xue, Shuwen | Liu, Jiaming | Qing, Xushun | Wang, Cunde
1-Cyanocyclopropane-1-carboxylates are reacted with arylhydrazines to afford 1,3,5-trisubstituted pyrazoles under the influence of a Brönsted acid. Formally, this transformation can be regarded as an annulation of three-membered rings with α-carbonyl and hydrazines. This newly efficient method provides access to a variety of structurally diverse pyrazole derivatives. The structures of five typical products were confirmed by X-ray crystallography.
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