Neuronal cell-surface protein neurexin 1 interaction with multi-PDZ domain protein MUPP1
2014
Jang, Won Hee | Chʻoe, Sŏn-hŭi | Jeong, Joo Young | Park, Jung-Hwa | Kim, Sang-jin | Seog, Dae-Hyun
Location of membrane proteins is often stabilized by PDZ domain-containing scaffolding proteins. Using the yeast two-hybrid screening, we found that neurexin 1 interacted with multi-PDZ domain protein 1 (MUPP1) through PDZ domain. Neurexin 2 and 3 also interacted with MUPP1. MUPP1 and neurexin 1 were co-localized in cultured cells. These results suggest a novel mechanism for localizing neurexin 1 to synaptic sites.
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