Rapid and Simple Access to α-(Hetero)arylacetonitriles from Gem-Difluoroalkenes
2022
Zhang, Jun-Qi | Liu, Jiayue | Hu, Dandan | Song, Jinyu | Zhu, Guorong | Ren, Hongjun
A scalable cyanation of gem-difluoroalkenes to (hetero)arylacetonitrile derivatives was developed. This strategy features mild reaction conditions, excellent yields, wide substrate scope, and broad functional group tolerance. Significantly, in this reaction, aqueous ammonia offers a “N” source for the “CN” reagent and entirely avoids the use of toxic cyanating reagents or metal catalysis. Hence, we provide a green and alternative method for the synthesis of arylacetonitriles.
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