Fluorescent trimethyl-substituted naphthyridine as a ligand for C–C mismatch detection in CCG trinucleotide repeats
2011
Sato, Yusuke | Honjo, Atsuko | Ishikawa, Daisuke | Nishizawa, Seiichi | Teramae, Norio
We report on the selective binding of 2-amino-5,6,7-trimethyl-1,8-naphthyridine (ATMND) to C–C mismatch present in the hairpin structures of (CCG)ₙ trinucleotide repeats that are associated with neurological diseases; this binding is accompanied by significant fluorescence quenching of ATMND.
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