A regioselective C7 bromination and C7 palladium-catalyzed Suzuki–Miyaura cross-coupling arylation of 4-substituted NH-free indazoles
2021
Boujdi, Khalid | El Brahmi, Nabil | Graton, Jérôme | Dubreuil, Didier | Collet, Sylvain | Mathé-Allainmat, Monique | Akssira, Mohamed | Lebreton, Jacques | El Kazzouli, Saïd
A direct and efficient regioselective C7-bromination of 4-substituted 1H-indazole has been achieved. Subsequently, a successful palladium-mediated Suzuki–Miyaura reaction of C7-bromo-4-substituted-1H-indazoles with boronic acids has been performed under optimized reaction conditions. A series of new C7 arylated 4-substituted 1H-indazoles was obtained in moderate to good yields.
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