Effects of lipoxygenase inhibitors in a model of lens-induced uveitis in dogs

Dziezyc, J.; Millichamp, N.J.; Rohde, B.H.; Baker, J.S.; Chiou, G.C.Y.

Effects of lipoxygenase inhibitors in a model of lens-induced uveitis in dogs

1989

Dziezyc, J. | Millichamp, N.J. | Rohde, B.H. | Baker, J.S. | Chiou, G.C.Y.

Uveitis was induced in dogs by intracameral injection of canine lens protein. The lipoxygenase inhibitors phenidone and norhydroguaiaretic acid, and dimethyl sulfoxide decreased fibrin production at 0.5 and 1 hour after induction uveitis. Phenidone and norhydroguaiaretic acid also inhibited the initial increase intraocular pressure early in the course of inflammation. Leukotriene B4 in the aqueous was measured by use of radioimmunoassay at 1 hour after inflammation. In control dogs, 230 to 1,700 pg of leukotriene B4/ml was measured; in dogs treated with phenidone, leukotriene, B4 was not measured.

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Ключевые слова АГРОВОК

animal animals dogs dogs drug therapy eye diseases eye lens inflammation lipoxygenase pharmacology uveitis

Библиографическая информация

Опубликовано в

American journal of veterinary research

ISSN 0002-9645

Издатель

Elsevier B.V.

Другие темы

Drug effects; Intraocular pressure; Inhibitors; Dimethyl sulfoxide; Veterinary; Dog diseases; Disease models; Lipoxygenase inhibitors; Masoprocol; Linoleate 13s-lipoxygenase; Therapeutic use; Disease models; Pyrazoles

Язык

Английский

Примечание

2019-12-05

Тип

Journal Article; Text

В АГРИСе с: 2024-02-29

Формат: MODS

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