Eight‐month repellency and efficacy of an imidacloprid/flumethrin (Seresto®) collar against the eastern paralysis tick (Ixodes holocyclus) on cats
2022
Smith, VM | de Burgh, SG | Jackson, CM | Chambers, MA | Page, PC
OBJECTIVE: The objective of this study was to determine the repellency and efficacy of a 10% imidacloprid/4.5% flumethrin (Seresto®, Elanco) collar over an 8‐month period against the eastern paralysis tick (Ixodes holocyclus) on cats. METHODS: Two non‐blinded, open gender, randomised, placebo‐controlled pen studies were conducted, with 26 cats enrolled in each study. Prior to inclusion, cats were immunised with I. holocyclus holocyclotoxin. Cats were treated on Day 0 with either an imidacloprid/flumethrin or placebo collar. Tick infestations with 20 unfed adult female eastern paralysis ticks commenced on Day 7, and were repeated monthly for 8 months. Repellency was determined by comparing the mean number of attached ticks on imidacloprid/flumethrin treated cats, to placebo collar treated cats at 6 and 24 h post infestation. Efficacy was determined by comparing the mean number of live ticks on imidacloprid/flumethrin collar treated cats to placebo collar treated cats at 72 h post infestation. RESULTS: Efficacy was 100% (P < 0.001) at 72 h, and repellency was greater than 96% (P < 0.001) at 24 h for every tick challenge in each of the two studies, from Day 7 to the final infestation at 8 months for imidacloprid/flumethrin collar treated cats. CONCLUSIONS: In two pen studies, an imidacloprid/flumethrin collar controlled and repelled the eastern paralysis tick (I. holocyclus) on cats for 8‐months. The marked repellency effect in addition to controlling tick paralysis would be beneficial in preventing tick bites and their sequelae.
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