Mangifera indica extract (Vimang) impairs aversive memory without affecting open field behaviour or habituation in rats

Preissler, Thales; Martins, Márcio Rodrigo; Pardo-Andreu, Gilberto L.; Henriques, João Antônio Pêgas; Quevedo, João; Delgado, René; Roesler, Rafael

Mangifera indica extract (Vimang) impairs aversive memory without affecting open field behaviour or habituation in rats

2009

Vimang is an aqueous extract of Mangifera indica L, used in Cuba for the treatment of immunopathological disorders. Increasing evidence from preclinical studies indicates that Vimang displays antioxidant, antiallergic, analgesic and antiinflammatory actions. The present study investigated the effects of systemic administration of Vimang on behavioural outcomes of neurological function in rats. A single oral administration of Vimang produced an impairment of short- and long-term retention of memory for aversive training when given either 1 h pretraining or immediately posttraining, but not 8 h posttraining. Vimang did not affect open field behaviour or habituation. The results indicate that Vimang might induce deficits of emotionally motivated memory without affecting nonassociative memory, locomotion, exploratory behaviour or anxiety.

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