Polycycloiridals with a Cyclopentane Ring from Iris tectorum
2017
Zhang, Chun-Lei | Hao, Zhi-You | Liu, Yan-Fei | Wang, Yan | Shi, Guo-Ru | Jiang, Zhi-Bo | Chen, Ruo-Yun | Cao, Zheng-Yu | Yu, De-Quan
Six new iridal-type triterpenoids containing an unprecedented cyclopentane ring, polycycloiridals E–J (1–6), were isolated from a large-scale re-extraction of Iris tectorum. A possible biosynthesis pathway is postulated. The known spirioiridotectal D (7) was also obtained in the current investigation, and its structure was unequivocally defined using X-ray diffraction data. Compound 7 suppressed LPS-activated NO production in the BV2 cell line with an IC₅₀ value of 0.54 μM.
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