Transgenic ablation of brown adipose tissue
1996
Lowell, B.B. | Susulic, V.S. | Hamann, A. | Lawitts, J.A. | Himms-Hagen, J. | Boyer, B.B. | Kozak, L. | Flier, J.S.
Brown fat is an important site of regulated energy expenditure. This observation has led to the suggestion that brown fat functions to maintain energy balance and prevent obesity. To directly test this hypothesis, we have produced transgenic mice that have a deficiency of brown fat due to the directed expression of diphtheria toxin A-chain. These animals are characterized by efficient metabolism and obesity. As the mice age, they also become hyperphagic, suggesting the possibility of a direct link between brown fat function and appetite regulation. In addition, obese animals develop severe insulin resistance. This study demonstrates that brown adipose tissue plays a critical role in the nutritional homeostasis of mice.
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