Chagas disease: the challenge of polyparasitism?
2014
Perez, Catherine J. | Lymbery, Alan J. | Thompson, R.C Andrew
The debilitating zoonosis Chagas disease (CD) is caused by infection with the flagellate protozoan Trypanosoma cruzi. One century after its discovery, a curative agent remains elusive. Immune evasion by T. cruzi results in a poorly controlled infection in the host, which can end in either sudden death or a fatal chronic disease that often eventuates after years of an asymptomatic infection. Polyparasitism or mixed/concurrent infections occur more often than not and contribute to the high degree of variability observed across both disease progression and the success of therapeutic interventions. A thorough understanding of the effects of polyparasitism on CD is essential for improving the likelihood of containing, treating, and eventually eliminating CD.
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