A convenient and mild method for 1,2,4-oxadiazole preparation: cyclodehydration of O-acylamidoximes in the superbase system MOH/DMSO
2016
Baykov, Sergey | Sharonova, Tatyana | Osipyan, Angelina | Rozhkov, Sergey | Shetnev, Anton | Smirnov, Alexey
Herein, we reported a general, convenient, and efficient synthesis of 3,5-disubstituted-1,2,4-oxadiazoles via cyclodehydration of O-acylamidoximes in the superbase system MOH/DMSO (M=Li, Na, K). Excellent isolated yields (up to 98%) were attained within short reaction times (10–20min). In addition, mild reaction conditions and a simple work-up procedure allow the synthesis of a wide range of heat-labile 1,2,4-oxadiazole-containing substances.
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