Drivers of Rift Valley fever epidemics in Madagascar.
Lancelot, Renaud | Béral, Marina | Rakotoharinome, Vincent Michel | Andriamandimby, Soa-Fy | Heraud, Jean-Michel | Coste, Caroline | Apolloni, Andrea | Squarzoni-Diaw, Cécile | de La Rocque, Stéphane | Formenty, Pierre B H | Bouyer, Jérémy | Wint, G R William | Cardinale, Eric | Animal, Santé, Territoires, Risques et Ecosystèmes (UMR ASTRE) ; Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut National de la Recherche Agronomique (INRA) | Centre de Recherche et de Veille sur les Maladies Émergentes dans l'Océan Indien (CRVOI) ; Université de La Réunion (UR) | Centre National de la Recherche Appliquée au Développement Rural (FOFIFA), DSV [Antananarivo] ; Direction des Services Vétérinaires, Ministère de l’Elevage | Unité d’Épidémiologie et de Recherche clinique [Antananarivo, Madagascar] ; Institut Pasteur de Madagascar ; Pasteur Network (Réseau International des Instituts Pasteur)-Pasteur Network (Réseau International des Instituts Pasteur) | Animal Production and Health Division [Rome] ; Food and Agriculture Organization of the United Nations [France] (FAO) ; Food and Agriculture Organization of the United Nations [Rome, Italie] (FAO)-Food and Agriculture Organization of the United Nations [Rome, Italie] (FAO) | World Organization for Animal Health | International Health Regulations Monitoring Procedure and Information Team ; Global Capacity and Response Department ; Organisation Mondiale de la Santé / World Health Organization Office [Genève, Suisse] (OMS / WHO)-Organisation Mondiale de la Santé / World Health Organization Office [Genève, Suisse] (OMS / WHO) | Emerging and Epidemic Zoonotic Diseases ; Pandemic and Epidemic Disease Department ; Organisation Mondiale de la Santé / World Health Organization Office [Genève, Suisse] (OMS / WHO)-Organisation Mondiale de la Santé / World Health Organization Office [Genève, Suisse] (OMS / WHO) | Department of Zoology [Oxford] ; University of Oxford | Cyclotron Réunion Océan Indien (CYROI) ; Université de La Réunion (UR)-Centre Hospitalier Universitaire de La Réunion (CHU La Réunion) | World Health Organization; Food and Agriculture Organization of the United Nations through the Central Emergency Response Fund of the United Nations; European Union [FP7-613996] | European Project: 613996,EC:FP7:KBBE,FP7-KBBE-2013-7-single-stage,VMERGE(2013)
International audience
Показать больше [+] Меньше [-]Английский. Rift Valley fever (RVF) is a vector-borne viral disease widespread in Africa. The primary cycle involves mosquitoes and wild and domestic ruminant hosts. Humans are usually contaminated after contact with infected ruminants. As many environmental, agricultural, epidemiological, and anthropogenic factors are implicated in RVF spread, the multidisciplinary One Health approach was needed to identify the drivers of RVF epidemics in Madagascar. We examined the environmental patterns associated with these epidemics, comparing human and ruminant serological data with environmental and cattle-trade data. In contrast to East Africa, environmental drivers did not trigger the epidemics: They only modulated local Rift Valley fever virus (RVFV) transmission in ruminants. Instead, RVFV was introduced through ruminant trade and subsequent movement of cattle between trade hubs caused its long-distance spread within the country. Contact with cattle brought in from infected districts was associated with higher infection risk in slaughterhouse workers. The finding that anthropogenic rather than environmental factors are the main drivers of RVF infection in humans can be used to design better prevention and early detection in the case of RVF resurgence in the region.
Показать больше [+] Меньше [-]Ключевые слова АГРОВОК
Библиографическая информация
Эту запись предоставил Institut national de la recherche agronomique