Anti-Müllerian hormone plasma concentration in prepubertal ewe lambs as a predictor of their fertility at a young age
Lahoz, Bernard | Alabart, José L. | Monniaux, Danielle | Mermillod, Pascal | Folch, José | Unidad de Tecnologia en produccion Animal ; Centro de Investigación y Tecnología Agroalimentaria de Aragón (CITA) | Unidad de Tecnologia en Produccion Animal ; Centro de Investigación y Tecnología Agroalimentaria de Aragón (CITA) | Physiologie de la reproduction et des comportements [Nouzilly] (PRC) ; Institut National de la Recherche Agronomique (INRA)-Institut Français du Cheval et de l'Equitation [Saumur] (IFCE)-Université de Tours (UT)-Centre National de la Recherche Scientifique (CNRS) | Unidad de Tecnologia en Produccion Animal ; Centro de Investigación y Tecnología Agroalimentaria de Aragón (CITA) | INIA (Ministerio de Ciencia e Innovacion, Spain) RTA-2011-128 RZP-2010-002
Plasma was taken from 76 Rasa Aragonesa ewe lambs at 3.6 months of age for AMH determination. Simultaneously, 600 IU equine chorionic gonadotropin (eCG) was administered and the number of ovulations recorded 6 days later. AMH was detected in 93% of the lambs, and the concentrations were about 3-4-fold higher in ovulating than in non-ovulating lambs (P < 0.004). Ewes aged around 10 months were mated, giving an overall fertility of 29%, and those failing to conceive were mated again 4 months later. Fertility at first mating was significantly correlated with plasma AMH concentration at 3.6 months (Spearman's rho = 0.34; P < 0.01). To use plasma AMH concentration as a screening test, a value of 97 pg/mL was determined as the optimum cutoff value to predict fertility at first mating (sensitivity = 68.2%; specificity = 72.2%). Fertility at first mating was 34.8 percentage points higher in ewe lambs with an AMH >= 97 pg/mL than in those with lower AMH concentrations (50% vs. 15%; P < 0.001).
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