Recent advances in candidate-gene and whole-genome approaches to the discovery of anthelmintic resistance markers and the description of drug/receptor interactions
Kotze, Andrew C. | Hunt, Peter W. | Skuce, Philip | von Samson-Himmelstjerna, Georg | Martin, Richard J. | Sager, Heinz | Krücken, Jürgen | Hodgkinson, Jane | Lespine, Anne | Jex, Aaron R. | Gilleard, John S. | Beech, Robin | Wolstenholme, Adrian J. | Demeler, Janina | Robertson, Alan P | Charvet, Claude | Neveu, Cédric | Kaminsky, Ronald | Rufener, Lucien | Alberich, Mélanie | Menez, Cécile | Prichard, Roger K. | Animal, Food and Health Sciences ; Commonwealth Scientific and Industrial Research Organisation [Australia] (CSIRO) | Moredun Research Institute [Penicuik, UK] (MRI) | Institute for Parasitology and Tropical Veterinary Medicine ; Freie Universität Berlin | Iowa State University (ISU) | Santé animale (S.A.) | Veterinary Parasitology ; Université Frères Mentouri – Constantine 1 = Constantine 1 – Frères Mentouri University (UMC) | University of Liverpool | ToxAlim (ToxAlim) ; Institut National de la Recherche Agronomique (INRA)-Université Toulouse III - Paul Sabatier (UT3) ; Université de Toulouse (UT)-Université de Toulouse (UT)-Ecole Nationale Vétérinaire de Toulouse (ENVT) ; Institut National Polytechnique (Toulouse) (Toulouse INP) ; Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National Polytechnique (Toulouse) (Toulouse INP) ; Université de Toulouse (UT)-Ecole d'Ingénieurs de Purpan (INP - PURPAN) ; Institut National Polytechnique (Toulouse) (Toulouse INP) ; Université de Toulouse (UT)-Université de Toulouse (UT) | University of Melbourne | Faculty of Veterinary Medicine ; University of Calgary | Institute of Parasitology ; McGill University = Université McGill [Montréal, Canada] | University of Georgia [USA] | Infectiologie et Santé Publique (UMR ISP) ; Institut National de la Recherche Agronomique (INRA)-Université de Tours (UT) | Université de Tours (UT) | NIH R01 AI047194
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Показать больше [+] Меньше [-]Английский. Anthelmintic resistance has a great impact on livestock production systems worldwide, is an emerging concern in companion animal medicine, and represents a threat to our ongoing ability to control human soil-transmitted helminths. The Consortium for Anthelmintic Resistance and Susceptibility (CARS) provides a forum for scientists to meet and discuss the latest developments in the search for molecular markers of anthelmintic resistance. Such markers are important for detecting drug resistant worm populations, and indicating the likely impact of the resistance on drug efficacy. The molecular basis of resistance is also important for understanding how anthelmintics work, and how drug resistant populations arise. Changes to target receptors, drug efflux and other biological processes can be involved. This paper reports on the CARS group meeting held in August 2013 in Perth, Australia. The latest knowledge on the development of molecular markers for resistance to each of the principal classes of anthelmintics is reviewed. The molecular basis of resistance is best understood for the benzimidazole group of compounds, and we examine recent work to translate this knowledge into useful diagnostics for field use. We examine recent candidate-gene and whole-genome approaches to understanding anthelmintic resistance and identify markers. We also look at drug transporters in terms of providing both useful markers for resistance, as well as opportunities to overcome resistance through the targeting of the transporters themselves with inhibitors. Finally, we describe the tools available for the application of the newest high-throughput sequencing technologies to the study of anthelmintic resistance.
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