Enterotypes of the human gut microbiome
2013
Arumugam, Manimozhiyan | Raes, Jeroen | Pelletier, Eric | Le Paslier, Denis | Yamada, Takuji | Mende, Daniel | Fernandes, Gabriel | Tap, Julien | Bruls, Thomas | Batto, Jean-Michel | Bertalan, Marcelo | Borruel, Natalia | Casellas, Francesc | Fernandez, Leyden | Gautier, Laurent | Hansen, Torben | Hattori, Masahira | Hayashi, Tetsuya | Kleerebezem, Michiel | Kurokawa, Ken | Leclerc, Marion | Levenez, Florence | Manichanh, Chaysavanh | Nielsen, H | Nielsen, Trine | Pons, Nicolas | Poulain, Julie | Qin, Junjie | Sicheritz-Ponten, Thomas | Tims, Sebastian | Torrents, David | Ugarte, Edgardo | Zoetendal, Erwin | Wang, Jun | Guarner, Francisco | Pedersen, Oluf | de Vos, Willem | Brunak, Søren | Doré, Joel | Weissenbach, Jean | Ehrlich, S | Bork, Peer | Génomique métabolique (UMR 8030) ; Genoscope - Centre national de séquençage [Evry] (GENOSCOPE) ; Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)) ; Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)) ; Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université d'Évry-Val-d'Essonne (UEVE)-Centre National de la Recherche Scientifique (CNRS) | Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE) | Lundbeck Foundation Centre for Applied Medical Genomics in Personalized Disease Prediction, Prevention and Care (LuCAMP); Novo Nordisk Foundation; International Science and Technology Cooperation Project in China [0806]; Agence Nationale de la Recherche (ANR); Institute for the encouragement of Scientific Research and Innovation of Brussels (ISRIB); Fund for Scientific Research Flanders (FWO) | European Project: 201052,EC:FP7:HEALTH,FP7-HEALTH-2007-A,METAHIT(2008)
International audience
Показать больше [+] Меньше [-]Английский. Our knowledge on species and function composition of the human gut microbiome is rapidly increasing, but it is still based on very few cohorts and little is known about their variation across the world. Combining 22 newly sequenced fecal metagenomes of individuals from 4 countries with previously published datasets, we identified three robust clusters (enterotypes hereafter) that are not nation or continent-specific. We confirmed the enterotypes also in two published, larger cohorts suggesting that intestinal microbiota variation is generally stratified, not continuous. This further indicates the existence of a limited number of well-balanced host-microbial symbiotic states that might respond differently to diet and drug intake. The enterotypes are mostly driven by species composition, but abundant molecular functions are not necessarily provided by abundant species, highlighting the importance of a functional analysis for a community understanding. While individual host properties such as body mass index, age, or gender cannot explain the observed enterotypes, data-driven marker genes or functional modules can be identified for each
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