Karyotype variation in neoplastic cells associated to severity of disseminated neoplasia in the cockle Cerastoderma edule
Matias, A. M. | Diaz, S. | Teixeira De Sousa, Joana | Villalba, A. | Carballal, M. J. | Leitao, A.
Disseminated neoplasia (DN) is characterized by an abnormal cell proliferation, usually resulting in death of the affected mollusks. In the present study we performed, for the first time, karyotypes of two different stages of DN in the cockle Cerastoderma edule. Analysis of moderate (N2) and high (N3) severity neoplasic metaphases displayed a chromosome number ranging from 57 to 317, instead of the normal diploid number of 38. Cockles with N2 showed a lower percentage of microchromosomes and a higher ploidy than those with N3. The comparison of both cytogenetic profiles contributes to better understand the evolution of DN in cockles.
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