Hypersaline fungi as a source of potentially active metabolites against pathogenic Candida species
2022
Panchal, Shweta | Murali, Thokur Sreepathy | Suryanarayanan, Trichur Subramanian et al.
Opportunistic and nosocomial human infections by various Candida species are of serious global health concern especially due to the spread of drug resistant strains and lack of treatment options. One of the main problems of bioprospecting for novel antimycotics is the rediscovery of already known molecules. To reduce the chances of such rediscoveries, one option is to search for unique metabolites from microbes of less studied and extreme habitats. Thirty-five fungal strains were isolated from solar salterns and the methanolic extracts of their culture supernatants were tested for the inhibition of human-pathogenic Candida albicans, C. dubliniensis, C. glabrata, C. lusitaniae, C. tropicalis, and two clinical isolates of C. auris. Of thefungi screened, two, viz. Curvularia nodosa and Fusarium cf. foetens, showed significant growth inhibition of all the Candida species.
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