The feather epithelium contributes to the dissemination and ecology of clade 2.3.4.4b H5 high pathogenicity avian influenza viruses in ducks
Gaide, Nicolas | Filaire, Fabien | Bertran, Kateri | Crispo, Manuela | Dirat, Malorie | Secula, Aurélie | Foret-Lucas, Charlotte | Payré, Bruno | Perlas, Albert | Cantero, Guillermo | Majó, Natàlia | Soubies, Sebastien Mathieu | Guérin, Jean-Luc | Interactions hôtes-agents pathogènes [Toulouse] (IHAP) ; Ecole Nationale Vétérinaire de Toulouse (ENVT) ; Institut National Polytechnique (Toulouse) (Toulouse INP) ; Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National Polytechnique (Toulouse) (Toulouse INP) ; Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE) | Animaux modèles pour la recherche en oncologie comparée (AMaROC) ; École nationale vétérinaire, agroalimentaire et de l'alimentation Nantes-Atlantique (ONIRIS) | THESEO BIOSECURITY | Centre de Recerca en Sanitat Animal [UAB, Spain] (CReSA) ; Universitat Autònoma de Barcelona = Autonomous University of Barcelona = Universidad Autónoma de Barcelona (UAB)-Institut de Recerca i Tecnologia Agroalimentàries = Institute of Agrifood Research and Technology (IRTA) | Centre de Microscopie Électronique Appliquée à la Biologie (CMEAB) ; Toulouse Réseau Imagerie-Genotoul (TRI-Genotoul) ; Université Toulouse III - Paul Sabatier (UT3) ; Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Toulouse III - Paul Sabatier (UT3) ; Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE) | This study was performed in the framework of the “Chaire de Biosécurité et Santé Aviaires”, hosted by the National Veterinary College of Toulouse (ENVT) and funded by the Direction Generale de l’Alimentation, Ministère de l’Agriculture et de la Souveraineté Alimentaire, France. The animal experiment was partially funded by the Veterinary Biocontained facility Network (VetBioNet) [EU Grant Agreement INFRA-2016-1 N°731014]. | European Project: 731014,VetBioNet(2017)
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Показать больше [+] Меньше [-]Английский. Immature feathers are known replication sites for high pathogenicity avian influenza viruses (HPAIVs) in poultry. However, it is unclear whether feathers play an active role in viral transmission. This study aims to investigate the contribution of the feather epithelium to the dissemination of clade 2.3.4.4b goose/Guangdong/1996 lineage H5 HPAIVs in the environment, based on natural and experimental infections of domestic mule and Muscovy ducks. During the 2016–2022 outbreaks, H5 HPAIVs exhibited persistent and marked feather epitheliotropism in naturally infected commercial ducks. Infection of the feather epithelium resulted in epithelial necrosis and disruption, as well as the production and environmental shedding of infectious virions. Viral and feather antigens colocalized in dust samples obtained from poultry barns housing naturally infected birds. In summary, the feather epithelium contributes to viral replication, and it is a likely source of environmental infectious material. This underestimated excretion route could greatly impact the ecology of HPAIVs, facilitating airborne and preening-related infections within a flock, and promoting prolonged viral infectivity and long-distance viral transmission between poultry farms.
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