Longitudinal Survey of Coronavirus Circulation and Diversity in Insectivorous Bat Colonies in Zimbabwe
Chidoti, Vimbiso | de Nys, Hélène | Pinarello, Valérie | Mashura, Getrude | Missé, Dorothée | Guerrini, Laure | Pfukenyi, Davies | Cappelle, Julien | Chiweshe, Ngoni | Ayouba, Ahidjo | Matope, Gift | Peeters, Martine | Gori, Elizabeth | Bourgarel, Mathieu | Liégeois, Florian | University of Zimbawe [Harare] (UZ) ; University of Zimbawe | Animal, Santé, Territoires, Risques et Ecosystèmes (UMR ASTRE) ; Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE) | Département Systèmes Biologiques (Cirad-BIOS) ; Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad) | Maladies infectieuses et vecteurs : écologie, génétique, évolution et contrôle (MIVEGEC) ; Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [Occitanie])-Université de Montpellier (UM) | Recherches Translationnelles sur le VIH et les maladies infectieuses endémiques et émergentes (TransVIHMI) ; Institut de Recherche pour le Développement (IRD)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM) | This work was supported by grants of the Agence Nationale de Recherche sur le SIDA et les Maladies Infectieuses (ANRS-COV10), the ANR (the French National Research Agency) under the "Investissements d'avenir" programme with the reference ANR-16-IDEX-0006) and the French Ministry of Europe and Foreign Affairs (Fond de Solidarite pour les Projets Innovants, les societes civiles, la francophonie et le developpement humain-CAZCOM Project) and the Agence Francaise pour le Developpement (AFD-PACMAN-Project). | ANR-16-IDEX-0006,MUSE,MUSE(2016)
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Показать больше [+] Меньше [-]Английский. Background: Studies have linked bats to outbreaks of viral diseases in human populations such as SARS-CoV-1 and MERS-CoV and the ongoing SARS-CoV-2 pandemic. Methods: We carried out a longitudinal survey from August 2020 to July 2021 at two sites in Zimbabwe with bat–human interactions: Magweto cave and Chirundu farm. A total of 1732 and 1866 individual bat fecal samples were collected, respectively. Coronaviruses and bat species were amplified using PCR systems. Results: Analysis of the coronavirus sequences revealed a high genetic diversity, and we identified different sub-viral groups in the Alphacoronavirus and Betacoronavirus genus. The established sub-viral groups fell within the described Alphacoronavirus sub-genera: Decacovirus, Duvinacovirus, Rhinacovirus, Setracovirus and Minunacovirus and for Betacoronavirus sub-genera: Sarbecoviruses, Merbecovirus and Hibecovirus. Our results showed an overall proportion for CoV positive PCR tests of 23.7% at Chirundu site and 16.5% and 38.9% at Magweto site for insectivorous bats and Macronycteris gigas, respectively. Conclusions: The higher risk of bat coronavirus exposure for humans was found in December to March in relation to higher viral shedding peaks of coronaviruses in the parturition, lactation and weaning months of the bat populations at both sites. We also highlight the need to further document viral infectious risk in human/domestic animal populations surrounding bat habitats in Zimbabwe.
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