Estimating the incidence of equine viral arteritis and the sensitivity of its surveillance in the French breeding stock.
Amat, J.P. | Vergne, T. | Tapprest, J. | Ferry, B. | Hans, A. | Hendrikx, P. | Dufour, Barbara | Leblond, Agnès | Laboratoire de Lyon [ANSES] ; Université de Lyon-Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES) | Veterinary Epidemiology, Economics and Public Health Group ; Royal Veterinary College | Laboratoire de pathologie équine de Dozulé ; Laboratoire de santé animale, sites de Maisons-Alfort et de Normandie ; Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES)-Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES) | Institut Français du Cheval et de l'Equitation | Ecologie et Ecophysiologie Forestières [devient SILVA en 2018] (EEF) ; Institut National de la Recherche Agronomique (INRA)-Université de Lorraine (UL) | Laboratory Affairs Department ; Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES) | Epidémiologie des maladies animales infectieuses (EpiMAI USC) ; École nationale vétérinaire d'Alfort (ENVA)-Epidémiologie (EPI) ; Laboratoire de santé animale, sites de Maisons-Alfort et de Normandie ; Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES)-Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES)-Laboratoire de santé animale, sites de Maisons-Alfort et de Normandie ; Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES)-Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES) | Unité de Recherche d'Épidémiologie Animale (UR EpiA) ; Institut National de la Recherche Agronomique (INRA)
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Показать больше [+] Меньше [-]Английский. Equine viral arteritis (EVA) may have serious economic impact on the equine industry. For this reason, it is monitored in many countries, especially in breeding stock, to avoid its spread during breeding activities. In France, surveillance is mainly based on serological tests, since mares are not vaccinated, but difficulties in interpreting certain series of results may impair the estimation of the number of outbreaks. In this study, we propose specific rules for identifying seroconversion in order to estimate the number of outbreaks that were detected by the breeding stock surveillance component (BSSC) in France between 2006 and 2013. A consensus among multidisciplinary experts was reached to consider seroconversion as a change in antibody titer from negative to at least 32, or as an eight-fold or greater increase in antibody level. Using these rules, 239 cases and 177 outbreaks were identified. Subsequently, we calculated the BSSC's sensitivity as the ratio of the number of detected outbreaks to the total number of outbreaks that occurred in breeding stock (including unreported outbreaks) estimated using a capture-recapture model. The total number of outbreaks was estimated at 215 (95% credible interval 195-249) and the surveillance sensitivity at 82% (CrI95% 71-91). Our results confirm EVA circulation in French breeding stock, show that neutralizing antibodies can persist up to eight years in naturally infected mares and suggest that certain mares have been reinfected. This study shows that the sensitivity of the BSSC is relatively high and supports its relevance to prevent the disease spreading through mating.
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