Molecular Characterization of Closely Related H6N2 Avian Influenza Viruses Isolated from Turkey, Egypt, and Uganda
Mercan, Yavuz | Atim, Gladys | Kayed, Ahmed | Azbazdar, M. Ekin | Kandeil, Ahmed | Ali, Mohamed | Rubrum, Adam | Mckenzie, Pamela | Webby, Richard | Erima, Bernard | Wabwire-Mangen, Fred | Ukuli, Qouilazoni | Tugume, Titus | Byarugaba, Denis | Kayali, Ghazi | Ducatez, Mariette | Koçer, Zeynep | Dokuz Eylül Üniversitesi = Dokuz Eylül University [Izmir] (DEÜ) | Izmir Biomedicine and Genome Center ; Dokuz Eylul University Health Campus | Makerere University [Kampala, Ouganda] (MAK) | Walter Reed Project ; Makerere University [Kampala, Ouganda] (MAK) | National Research Centre - NRC (EGYPT) | St Jude Children's Research Hospital [Memphis, USA] | The University of Texas Health Science Center at Houston (UTHealth) | Human Link | Interactions hôtes-agents pathogènes [Toulouse] (IHAP) ; Ecole Nationale Vétérinaire de Toulouse (ENVT) ; Institut National Polytechnique (Toulouse) (Toulouse INP) ; Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National Polytechnique (Toulouse) (Toulouse INP) ; Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE) | The part of this study that was performed in Turkey was funded by Izmir Biomedicine and Genome Center. The Egyptian and Ugandan parts of the study was funded by the National Institute of Allergy and Infectious Diseases, the National Institutes of Health, under contract number HHSN272201400006C.
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Показать больше [+] Меньше [-]Английский. Genetic analysis of circulating avian influenza viruses (AIVs) in wild birds at different geographical regions during the same period could improve our knowledge about virus transmission dynamics in natural hosts, virus evolution as well as zoonotic potential. Here, we report the genetic and molecular characterization of H6N2 influenza viruses isolated from migratory birds in Turkey, Egypt, and Uganda during 2017–2018. The Egyptian and Turkish isolates were genetically closer to each other than they were to the virus isolated from Uganda. Our results also suggest that multiple reassortment events were involved in the genesis of the isolated viruses. All viruses contained molecular markers previously associated with increased replication and/or pathogenicity in mammals. The results of this study indicate that H6N2 viruses carried by migratory birds on the West Asian/East African and Mediterranean/Black Sea flyways have the potential to transmit to mammals including humans. Additionally, adaptation markers in these viruses indicate the potential risk for poultry, which also increases the possibility of human exposure to these viruses.
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