Structures, Occurrences and Biosynthesis of 11,12,13-Tri-nor-Sesquiterpenes, an Intriguing Class of Bioactive Metabolites
Coca Ruiz, Víctor | Suárez Cáceres, Ivonne Rocío | Aleu Casatejada, Josefina | González Collado, Isidro | Biomedicina, Biotecnología y Salud Pública | Química Orgánica
The compounds 11,12,13-tri-nor-sesquiterpenes are degraded sesquiterpenoids which have lost the C-3 unit of isopropyl or isopropenyl at C-7 of the sesquiterpene skeleton. The irregular C-backbone originates from the oxidative removal of a C-3 side chain from the C-15 sesquiterpene, which arises from farnesyl diphosphate (FDP). The C-12 -framework is generated, generally, in all families of sesquiterpenes by oxidative cleavage of the C-3 substituent, with the simultaneous introduction of a double bond. This article reviews the isolation, biosynthesis and biological activity of this special class of sesquiterpenes, the 11,12,13-tri-nor-sesquiterpenes.
Показать больше [+] Меньше [-]This research was supported by grant from MICIU (RTI2018-097356-B-C21, MCIU/AEI/FEDER, EU).
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