Efficacy of non-pharmacological interventions to treat malnutrition in older persons: A systematic review and meta-analysis. The SENATOR project ONTOP series and MaNuEL Knowledge Hub project
2019
Correa-Perez, A. | Abraha, Iosef | Cherubini, Antonio | Collinson, Avril | Dardevet, Dominique | de Groot, Lisette C. | de van Der Schueren, Marian A. E. | Hebestreit, Antje | Hickson, Mary | Jaramillo-Hidalgo, Javier | Lozano-Montoya, Isabel | O'Mahony, Denis | Soiza, Roy L. | Visser, Marjolein | Volkert, Dorothee | Wolters, Maike | Jentoft, Alfonso J. C. | Servicio de Geriatría ; Instituto Ramon y Cajal de Investigacion Sanitaria [Madrid, Spain] (IRYCIS) ; Universidad de Alcalá [Alcalá de Henares, España] = University of Alcalá [Alcalá de Henares, Spain] = Université d'Alcalá [Alcalá de Henares, Espagne] (UAH)-Universidad de Alcalá [Alcalá de Henares, España] = University of Alcalá [Alcalá de Henares, Spain] = Université d'Alcalá [Alcalá de Henares, Espagne] (UAH) | Italian National Research Centre on Aging (INRCA) | Institute of Health and Community | Plymouth University | Unité de Nutrition Humaine (UNH) ; Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]) | Division of Human Nutrition and Health ; Wageningen University and Research [Wageningen] (WUR) | department of nutrition and health ; HAN University of Applied sciences | department of nutrition and dietetics ; VU University Amsterdam Medical Center | Leibniz Institute for Prevention Research and Epidemiology - BIPS ; Leibniz Association | Servicio de Geriatría ; Hospital Central de la Cruz Roja San José y Santa Adela | Department of Geriatric Medicine ; Oslo University Hospital [Oslo] | Department of Medicine for the Elderly ; Grampian University Hospitals NHS Trust | Friedrich-Alexander Universität Erlangen-Nürnberg = University of Erlangen-Nuremberg (FAU) | MalNutrition in the ELderly (MaNuEL) knowledge hub Joint Programming Initiative 'Healthy Diet for a Healthy Life' from the European Union's H2020 Research and Innovation Programme 696300SENATOR from the European Union 305930 | European Project: 696300,H2020,H2020-ISIB-2015-1,CSA JPI HDHL 2.0(2016)
INTRODUCTION: We aimed to perform a review of SRs of non-pharmacological interventions in older patients with well-defined malnutrition using relevant outcomes agreed by a broad panel of experts. METHODS: PubMed, Cochrane, EMBASE, and CINHAL databases were searched for SRs. Primary studies from those SRs were included. Quality assessment was undertaken using Cochrane and GRADE criteria. RESULTS: Eighteen primary studies from seventeen SRs were included. Eleven RCTs compared oral nutritional supplementation (ONS) with usual care. No beneficial effects of ONS treatment, after performing two meta-analysis in body weight changes (six studies), mean difference: 0.59 (95%CI -0.08, 1.96) kg, and in body mass index changes (two studies), mean difference: 0.31 (95%CI -0.17, 0.79) kg/m2 were found. Neither in MNA scores, muscle strength, activities of daily living, timed Up&Go, quality of life and mortality. Results of other intervention studies (dietary counselling and ONS, ONS combined with exercise, nutrition delivery systems) were inconsistent. The overall quality of the evidence was very low due to risk of bias and small sample size. CONCLUSIONS: This review has highlighted the lack of high quality evidence to indicate which interventions are effective in treating malnutrition in older people. High quality research studies are urgently needed in this area.
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