Ergogenic effects of quercetin supplementation in trained rats
Casuso Rafael A | Martínez-Amat Antonio | Martínez-López Emilio J | Camiletti-Moirón Daniel | Porres Jesus M | Aranda Pilar
<p>Abstract</p> <p>Background</p> <p>Quercetin is a natural polyphenolic compound currently under study for its ergogenic capacity to improve mitochondrial biogenesis. Sedentary mice have exhibited increased endurance performance, but results are contradictory in human models.</p> <p>Methods</p> <p>We examined the effects of six weeks of endurance training and quercetin supplementation on markers of endurance performance and training in a rodent model. Rats were randomly assigned to one of the following groups: placebo+sedentary (PS), quercetin+sedentary (QS), placebo+endurance training (PT) and quercetin+endurance training (QT). Quercetin was administered at a dose of 25 mg/kg on alternate days. During six weeks of treatment volume parameters of training were recorded, and after six weeks all groups performed a maximal graded VO<sub>2</sub> max test and a low-intensity endurance run-to-fatigue test.</p> <p>Results</p> <p>No effects were found in VO<sub>2</sub> peak (p>0.999), nor in distance run during low-intensity test, although it was 14% greater in QT when compared with PT (P = 0.097). Post-exercise blood lactate was increased in QT when compared with PT (p=0.023) and also in QS compared with PS (p=0.024).</p> <p>Conclusions</p> <p>This study showed no effects in VO<sub>2</sub> peak, speed at VO<sub>2</sub> peak or endurance time to exhaustion after six weeks of quercetin supplementation compared with placebo in trained rats. Quercetin was show to increase blood lactate production after high-intensity exercise.</p>
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