A randomized, double-blind, placebo-controlled, pilot study to evaluate the effect of whole grape extract on antioxidant status and lipid profile
Malkanthi Evans | Dale Wilson | Najla Guthrie
The health benefits of grapes, which contain polyphenols, are well documented. The antioxidative and cardioprotective effects of a whole grape extract (WGE) were studied in a single-centre, randomized, double-blind, placebo-controlled, 6-week pilot study conducted on 24 pre-hypertensive, overweight, and/or pre-diabetic subjects. Blood and urine biomarkers of antioxidant status were assessed at the beginning and end of the study. WGE subjects had significantly lower superoxide dismutase concentrations (P = 0.032) and total cholesterol/HDL-C ratios (P = 0.037), and significantly higher HDL-C levels (P = 0.001) compared to the placebo subjects after 6 weeks. The concentration of 8-isoprostane and oxidized LDL decreased by 5% and 0.5%, respectively, for WGE subjects, but increased by 50% and 5%, respectively, for the placebo subjects. This is the first North American study to report efficacy of WGE on antioxidant status and lipid profile.
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