Pharmacogenetics of hypoglycemic agents
2015
Irina Vladimirovna Kononenko | Aleksandr Yuryevich Mayorov | Ekaterina Olegovna Koksharova | Marina Vladimirovna Shestakova
Despite the increase in the number of hypoglycemic agents, 35%–40% of patients with diabetes are unable to achieve adequate glycemic control. One of the reasons is the genetic heterogeneity of diabetes mellitus, requiring different treatment approaches; however, the individual metabolic features and sensitivity to drugs also affect the therapeutic effectiveness. The review presents the main results of pharmacogenetic research of several antidiabetic drugs: metformin, sulfonylurea, agonists of glucagon-like peptide-1 and thiazolidinediones.
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