高油酸葵花籽油与油茶籽油的抗炎、抗刺激 及抗湿疹功效研究Anti-inflammatory, anti-irritation and anti-eczema effects of high oleic acid sunflower seed oil and oil-tea camellia seed oil

旨在为油茶籽油与高油酸葵花籽油在化妆品中的应用提供数据支撑，通过体外3D表皮模型EpiKutis构建体外急性损伤及类湿疹表皮模型，以低温压榨高油酸葵花籽油和油茶籽油处理模型，检测其组织活力、炎症因子释放量、组织形态结构和胸腺基质淋巴细胞生成素（TSLP）含量，评价高油酸葵花籽油和油茶籽油的抗炎、抗刺激、抗湿疹功效。结果表明：高油酸葵花籽油与油茶籽油对模型组织活力均无显著影响；油茶籽油能显著降低模型炎症因子释放量，而高油酸葵花籽油不能显著降低模型炎症因子释放量；高油酸葵花籽油与油茶籽油对模型组织形态结构均有一定改善；高油酸葵花籽油与油茶籽油均能极显著降低模型TSLP含量。综上，油茶籽油与高油酸葵花籽油对皮肤刺激性炎症均具有一定的抑制和缓解作用，具有显著的抗湿疹功效；同时，油茶籽油对皮肤刺激性损伤具有一定的抑制和缓解作用。Aiming to provide data support for the application of oil-tea camellia seed oil and high oleic acid sunflower seed oil in cosmetics,3D epidermal model EpiKutis was used to construct acute injury and eczema-like epidermal models in vitro, the models were treated by cold-pressed high oleic acid sunflower seed oil and oil-tea camellia seed oil, and the anti-inflammatory, anti-irritation and anti-eczema effects of high oleic acid sunflower seed oil and oil-tea camellia seed oil were evaluated by examining the tissue vitality, the release of inflammatory factors, the changes of tissue morphology and structure, and the content of thymus stromal lymphogenesis hormone (TSLP) of the models.The results showed that high oleic acid sunflower seed oil and oil-tea camellia seed oil had no significant effect on tissue vitality, oil-tea camellia seed oil could significantly reduce the release of inflammatory factors, but high oleic acid sunflower seed oil could not. High oleic acid sunflower seed oil and oil-tea camellia seed oil could improve tissue morphology and structure to some extent, and significantly reduce the content of TSLP. To sum up, both oil-tea camellia seed oil and high oleic acid sunflower seed oil have certain inhibition and relief effects on skin irritant inflammation, and have significant anti-eczema effects. At the same time,oil-tea camellia seed oil also has a certain inhibition and relief effect on skin irritant damage.