Differences in the expression of selected genes associated with cell stress response in a PTSD patient and in healthy individuals – a case study
Anna Rasmus | Paweł Półrola | Jolanta Góral-Półrola | Małgorzata Żychowska | Andrzej Mirski | Henryk Knapik
Objective The aim of the study was determination of the level in expression genes associated with cell stress response in a patient with PTSD. Case study A 57-year-old PTSD patient, A.P., was the subject of the study. Blood samples were taken from the ulnar vein to assess the relative expression of the tested genes in leukocytes via a quantitative reverse transcription polymerase chain reaction (qRT-PCR). Results A considerably decreased level in the expression HSF-1, NF-kB, Hif-1 and IL6 m-RNA was observed in the patient when compared to the control group. A low expression in HSPA1A, HSPB1, IL10 and CRP m-RNA compared with the control group was also noted. Conclusions It is possible that the lower level of transcriptional factors: HSF-1, NF-kB and Hif-1 as well as IL6 m-RNA may be associated with the effect of the PTSD patient’s treatment.
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