Effect of peanut addition to the cafeteria diet on adiposity and inflammation in zebrafish (Danio rerio)
Vanessa Bueno Moreira Javera Castanheira Néia | Eliane Papa Ambrosio-Albuquerque | Ingrid de Lima Figueiredo | Thibério Carvalho da Silva | Vanessa Lewandowski | Fernanda Losi Alves de Almeida | Ricardo Pereira Ribeiro | Jeane Eliete Laguila Visentainer | Jesuí Vergilio Visentainer
Zebrafish (Danio rerio) emerged as a model of diet-induced obesity because of its genetic homology to humans. Peanut is a rich source of monounsaturated fatty acid and its consumption is associated with decreased inflammatory markers and obesity control. This study evaluated the effects of peanut addition to the cafeteria diet (CAF) by analysis of fatty acids into the head, adiposity and expression of TNF, IL6 and FASN genes using zebrafish as experimental model. The zebrafish were maintained in tanks for 60 days and treated with standard (ST) and CAF diets, respectively. The CAF diet increased the oleic acid content in zebrafish heads, however the body weight, body mass index, adipose tissue and expression of inflammatory and lipid metabolism genes did not differ between the groups. This study suggests that the addition of peanut in the CAF diet can control weight gain, the inflammatory markers and lipid metabolism in zebrafish model.
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