Post-Translational Modifications in Atopic Dermatitis: Current Research and Clinical Relevance
2022
Xin Ma | Xin Ma | Yi Ru | Yi Ru | Ying Luo | Ying Luo | Le Kuai | Le Kuai | Qi-Long Chen | Yun Bai | Ye-Qiang Liu | Jia Chen | Yue Luo | Jian-Kun Song | Mi Zhou | Mi Zhou | Bin Li | Bin Li
Atopic dermatitis (AD) is a chronic and relapsing cutaneous disorder characterized by compromised immune system, excessive inflammation, and skin barrier disruption. Post-translational modifications (PTMs) are covalent and enzymatic modifications of proteins after their translation, which have been reported to play roles in inflammatory and allergic diseases. However, less attention has been paid to the effect of PTMs on AD. This review summarized the knowledge of six major classes (including phosphorylation, acetylation, ubiquitination, SUMOylation, glycosylation, o-glycosylation, and glycation) of PTMs in AD pathogenesis and discussed the opportunities for disease management.
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