Resveratrol-Based Nanoformulations as an Emerging Therapeutic Strategy for Cancer
2021
Javad Sharifi-Rad | Cristina Quispe | Zhazira Mukazhanova | Ewa Knut | Aknur Turgumbayeva | Aknur Turgumbayeva | Aliya Kipchakbayeva | Gulnaz Seitimova | Mohamad Fawzi Mahomoodally | Devina Lobine | Aaron Koay | Jinfan Wang | Helen Sheridan | Gerardo Leyva-Gómez | María L. Del Prado-Audelo | Hernán Cortes | Antonio Rescigno | Paolo Zucca | Oksana Sytar | Oksana Sytar | Muhammad Imran | Célia F. Rodrigues | Natália Cruz-Martins | Natália Cruz-Martins | Natália Cruz-Martins | Halina Ekiert | Manoj Kumar | Ahmad Faizal Abdull Razis | Ahmad Faizal Abdull Razis | Usman Sunusi | Usman Sunusi | Ramla Muhammad Kamal | Ramla Muhammad Kamal | Agnieszka Szopa
Resveratrol is a polyphenolic stilbene derivative widely present in grapes and red wine. Broadly known for its antioxidant effects, numerous studies have also indicated that it exerts anti-inflammatory and antiaging abilities and a great potential in cancer therapy. Regrettably, the oral administration of resveratrol has pharmacokinetic and physicochemical limitations such as hampering its effects so that effective administration methods are demanding to ensure its efficiency. Thus, the present review explores the published data on the application of resveratrol nanoformulations in cancer therapy, with the use of different types of nanodelivery systems. Mechanisms of action with a potential use in cancer therapy, negative effects, and the influence of resveratrol nanoformulations in different types of cancer are also highlighted. Finally, the toxicological features of nanoresveratrol are also discussed.
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