Molecular basis of IRGB10 oligomerization and membrane association for pathogen membrane disruption
2021
Hyun Ji Ha | Hye Lin Chun | So Yeon Lee | Jae-Hee Jeong | Yeon-Gil Kim | Hyun Ho Park
Ha et al. present a crystal structure of mouse IRGB10, a mouse interferon-inducible GTPase that mediates bacteriolysis in cell autonomous immunity. With further mutagenesis studies, they show that IRGB10 bound to GDP forms an inactive head-to-head dimer, which changes its conformation to activate its membrane-binding and disruptive functions.
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