The metabolic stress-activated checkpoint LKB1-MARK3 axis acts as a tumor suppressor in high-grade serous ovarian carcinoma
2022
Hidenori Machino | Syuzo Kaneko | Masaaki Komatsu | Noriko Ikawa | Ken Asada | Ryuichiro Nakato | Kanto Shozu | Ai Dozen | Kenbun Sone | Hiroshi Yoshida | Tomoyasu Kato | Katsutoshi Oda | Yutaka Osuga | Tomoyuki Fujii | Gottfried von Keudell | Vassiliki Saloura | Ryuji Hamamoto
Machino et al discover that low expression of microtubule affinity-regulating kinase 3 (MARK3) correlates with poor prognosis in high-grade serous ovarian carcinoma (HGSOC) patients. They find that the LKB1-MARK3 axis is activated by metabolic stress to block the cell cycle at the G2/M checkpoint, and characterise other MARK3 regulated pathways through RNA and ATAC sequencing.
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