Association of Single Nucleotide Polymorphisms from Angiogenesis-Related Genes, <i>ANGPT2</i>, <i>TLR2</i> and <i>TLR9,</i> with Spontaneous Preterm Labor
Wioletta Izabela Wujcicka | Marian Kacerovsky | Adrian Krygier | Michał Krekora | Piotr Kaczmarek | Mariusz Grzesiak
In this study, we hypothesized that the changes localized at angiopoietin-2 (<i>ANGPT2</i>), granulocyte-macrophage colony-stimulating factor (<i>CSF2</i>), fms-related tyrosine kinase 1 (<i>FLT1</i>) and toll-like receptor (<i>TLR</i>) <i>2</i>, <i>TLR6</i> and <i>TLR9</i> genes were associated with spontaneous preterm labor (PTL), as well as with possible genetic alterations on PTL-related coagulation. This case-control genetic association study aimed to identify single nucleotide polymorphisms (SNPs) for the aforementioned genes, which are correlated with genetic risk or protection against PTL in Polish women. The study was conducted in 320 patients treated between 2016 and 2020, including 160 women with PTL and 160 term controls in labor. We found that <i>ANGPT2</i> rs3020221 AA homozygotes were significantly less common in PTL cases than in controls, especially after adjusting for activated partial thromboplastin time (APTT) and platelet (PLT) parameters. TC heterozygotes for <i>TLR2</i> rs3804099 were associated with PTL after correcting for anemia, vaginal bleeding, and history of threatened miscarriage or PTL. TC and CC genotypes in <i>TLR9</i> rs187084 were significantly less common in women with PTL, compared to the controls, after adjusting for bleeding and gestational diabetes. For the first time, it was shown that three polymorphisms—<i>ANGPT2</i> rs3020221, <i>TLR2</i> rs3804099 and <i>TLR9</i> rs187084 —were significantly associated with PTL, adjusted by pregnancy development influencing factors.
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