Asymmetric Mach–Zehnder Interferometer Based Biosensors for Aflatoxin M1 Detection
2016
Tatevik Chalyan | Romain Guider | Laura Pasquardini | Manuela Zanetti | Floris Falke | Erik Schreuder | Rene G. Heideman | Cecilia Pederzolli | Lorenzo Pavesi
In this work, we present a study of Aflatoxin M1 detection by photonic biosensors based on Si3N4 Asymmetric Mach–Zehnder Interferometer (aMZI) functionalized with antibodies fragments (Fab′). We measured a best volumetric sensitivity of 104 rad/RIU, leading to a Limit of Detection below 5 × 10−7 RIU. On sensors functionalized with Fab′, we performed specific and non-specific sensing measurements at various toxin concentrations. Reproducibility of the measurements and re-usability of the sensor were also investigated.
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