Transcriptome-Based Identification and Molecular Evolution of the <em>Cytochrome P450</em> Genes and Expression Profiling under Dimethoate Treatment in Amur Stickleback (<em>Pungitius sinensis</em>)
Jun Cao | Xiuzhu Cheng
Cytochrome P450s (CYPs) are a family of membrane-bound mono-oxygenase proteins, which are involved in cell metabolism and detoxification of various xenobiotic substances. In this study, we identified 58 putative <i>CYP</i> genes in Amur stickleback (<i>Pungitius sinensis</i>) based on the transcriptome sequencing. Conserved motif distribution suggested their functional relevance within each group. Some present recombination events have accelerated the evolution of this gene family. Moreover, a few positive selection sites were identified, which may have accelerated the functional divergence of this family of proteins. Expression patterns of these <i>CYP</i> genes were investigated and indicated that most were affected by dimethoate treatment, suggesting that <i>CYPs</i> were involved in the detoxication of dimethoate. This study will provide a foundation for the further functional investigation of <i>CYP</i> genes in fishes.
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