Protective Effect of <i>Litchi chinensis</i> Peel Extract-Prepared Nanoparticles on Rabbits Experimentally Infected with <i>Eimeria stiedae</i>
Dina M. Metwally | Afrah F. Alkhuriji | Ibrahim A. H. Barakat | Hanadi B. Baghdadi | Manal F. El-Khadragy | Wafa Abdullah I. Al-Megrin | Abdullah D. Alanazi | Fatemah E. Alajmi
The present study used <i>Litchi chinensis</i> peel extract to synthesize silver nanoparticles (AgNPs). This technique is eco-friendly and can be performed in a single step; thus, it has attracted great attention for NPs biosynthesis. Herein, we biosynthesized AgNPs with <i>L. chinensis</i> peel extract and examined their anticoccidial activity in rabbit hepatic coccidiosis induced by <i>E. stiedae</i> infection. Thirty-five rabbits were allocated into seven groups: a healthy group (G1), an infected control group (G2), four groups infected before treatment with 10 mg/kg <i>L. chinensis</i> peel extract-biosynthesized AgNPs (G3, G5) or 50 mg/kg amprolium (G4, G6), and rabbits infected after two weeks of pretreatment with 10 mg/kg <i>L. chinensis</i> eel extract-biosynthesized AgNPs (G7). In this study, both pre-and post-treatment with AgNPs produced a substantial reduction in fecal oocyst output, liver enzyme levels, and histopathological hepatic lesions relative to the infected group. In conclusion, <i>L. chinensis</i> peel extract-prepared AgNPs should be considered harmless and efficient in the cure of hepatic coccidiosis in rabbits.
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