Detection and Genomic Characterization of Canine Circovirus in Iran
Farzad Beikpour | Linda Amarachi Ndiana | Alireza Sazmand | Paolo Capozza | Farzad Nemati | Francesco Pellegrini | Salman Zafari | Seyed Masoud Zolhavarieh | Roberta Cardone | Reza Faraji | Gianvito Lanave | Vito Martella | Nicola Decaro
Canine circovirus (CaCV) is a single-stranded DNA virus that globally circulates in dogs and wild carnivores. Although the pathogenic potential of the virus has not been fully understood yet, CaCV has been suggested to exacerbate the clinical course of other canine viral infections but also to circulate in dogs without clinical signs. In this study, we carried out real-time PCR assays to detect enteric pathogens from 156 canine rectal swabs collected from dogs without enteritis in 3 different regions in Iran. A total of 14 samples tested positive for CaCV and full-length genome sequences were obtained from 6 of the detected strains. Sequence and phylogenetic analyses showed that, despite the distance between the different sample collection sites, all Iranian CaCV strains were closely related and formed a separate clade from extant CaCVs. The present study shows that CaCV is circulating in non-diarrheic dogs in Iran, thus highlighting the need for further epidemiological investigations in Iranian domestic and wild carnivores.
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